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  Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age

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Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age Vide
PostSubject: Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age    Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age Icon_minitimeTue Jan 30, 2018 6:39 pm
The longest-lived rodent, the naked mole-rat (Heterocephalus glaber), has a reported maximum lifespan of >30 years and exhibits delayed and/or attenuated age-associated physiological declines. We questioned whether these mouse-sized, eusocial rodents conform to Gompertzian mortality laws by experiencing an exponentially increasing risk of death as they get older. We compiled and analyzed a large compendium of historical naked mole-rat lifespan data with >3000 data points. Kaplan-Meier analyses revealed a substantial portion of the population to have survived at 30 years of age. Moreover, unlike all other mammals studied to date, and regardless of sex or breeding-status, the age-specific hazard of mortality did not increase with age, even at ages 25-fold past their time to reproductive maturity. This absence of hazard increase with age, in defiance of Gompertz’s law, uniquely identifies the naked mole-rat as a non-aging mammal, confirming its status as an exceptional model for biogerontology.

Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age Images?q=tbn:ANd9GcSdjRItc-xS5gZFOFBpeA3WcnOvy9Fx0IpwQHQYe5-MeboGZhWFewjfgs5dkVa6ekkjbvbpuJdnk3w

https://elifesciences.org/articles/31157
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Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age

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